解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Indian and Chinese rhesus macaques are often used in biomedical research. Genetic analyses of the major histocompatibility class I region have revealed that these macaques display a substantial level of polymorphism at Mamu-A and Mamu-B loci, which have been subject to duplication. Only a few Mamu class I allotypes ar...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-013-0734-5
更新日期:2013-12-01 00:00:00
abstract::We report on the analyses of genes encoding immunoglobulin heavy and light chains in the rabbit 6.51× whole genome assembly. This OryCun2.0 assembly confirms previous mapping of the duplicated IGK1 and IGK2 loci to chromosome 2 and the IGL lambda light chain locus to chromosome 21. The most frequently rearranged and e...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-013-0722-9
更新日期:2013-10-01 00:00:00
abstract::Cytotoxic CD8+ T-cell immunosurveillance for intracellular pathogens, such as viruses, is controlled by classical major histocompatibility complex (MHC) class Ia molecules, and ideally, these antiviral T-cell populations are defined by the specific peptide and restricting MHC allele. Surprisingly, despite the utility ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-013-0711-z
更新日期:2013-09-01 00:00:00
abstract::Immunoglobulin E (IgE) provides important information on the humoral immune status, and the IgE level is routinely detected in clinical practice. There are many diseases associated with IgE, such as atopic disease, autoimmune diseases, and so on. IgE is a genetically complex trait, but comprehensive genetic assessment...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-013-0706-9
更新日期:2013-08-01 00:00:00
abstract::To identify novel mechanisms regulating allogeneic hematopoietic cell engraftment, we used forward genetics and previously described identification, in mice, of a bone marrow (BM) engraftment quantitative trait locus (QTL), termed Bmgr5. This QTL confers dominant and large allele effects for engraftment susceptibility...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-013-0709-6
更新日期:2013-08-01 00:00:00
abstract::The polymorphism of major histocompatibility complex class I chain-related gene B (MICB) and variations in MICB alleles in a variety of populations have been characterized using several genotyping approaches. In the present study, a novel polymerase chain reaction sequence-based typing (PCR-SBT) method was established...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-013-0699-4
更新日期:2013-07-01 00:00:00
abstract::The tripartite motif protein (TRIM)5α/CypA fusion protein TRIMCyp in Old World monkeys is generally considered unable to restrict HIV-1 replication. Monkeys with TRIMCyp can serve as a unique animal model for studies of HIV-1 infection. The present study investigated the distribution and expression status of TRIMCyp i...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-012-0670-9
更新日期:2013-03-01 00:00:00
abstract::The major histocompatibility complex (MHC) includes highly polymorphic gene families encoding proteins crucial to the vertebrate acquired immune system. Classical MHC class I (MHCI) genes code for molecules expressed on the surfaces of most nucleated cells and are associated with defense against intracellular pathogen...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-012-0669-2
更新日期:2013-03-01 00:00:00
abstract::Over a period of some 20 years, Werner Eugen Mayer played a significant role in establishing a framework for molecular studies of Mhc genes in multiple vertebrates. His work largely concerned gene isolation, sequencing, and related bioinformatic analyses both for the Mhc and for immune system genes of about 200 specie...
journal_title:Immunogenetics
pub_type: 传,历史文章,杂志文章,评审
doi:10.1007/s00251-012-0654-9
更新日期:2012-12-01 00:00:00
abstract::Alpha-2-macroglobulin (A2M) binds proteases, thereby acting as defense barriers against pathogens in the plasma and tissues of vertebrates and invertebrates. Quantitative real-time polymerase chain reaction (PCR) and the isobaric tags for relative and absolute quantitation method were used to determine the expression ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-012-0639-8
更新日期:2012-11-01 00:00:00
abstract::In the present study, we investigate patterns of variation in the KIR cluster in a large and well-characterized sample of worldwide human populations in the Human Genome Diversity Project-Centre d'Etude du Polymorphisme Humain (HGDP-CEPH) panel in order to better understand the patterns of diversity in the region. Com...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-012-0629-x
更新日期:2012-10-01 00:00:00
abstract::Knowledge about the magnitude of individual polymorphism is a critical part in understanding the complexity of comprehensive mismatching. HLA-B*44:09 differs from the highly frequent HLA-B*44:02 allele by amino acid exchanges at residues 77, 80, 81, 82 and 83. We aimed to identify the magnitude of these mismatches on ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-012-0625-1
更新日期:2012-09-01 00:00:00
abstract::The cattle major histocompatibility complex (MHC) region contains a variable number of classical class I genes encoding polymorphic molecules involved in antigen presentation. Six classical class I genes have been described, but assigning sequences to these genes has proved problematic. We propose a refinement of the ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-012-0611-7
更新日期:2012-06-01 00:00:00
abstract::T-bet is a key regulator for the lineage commitment in CD4+ T helper (Th) 1 cells by activating the hallmark production of interferon-γ. Previously, two single nucleotide polymorphisms (SNPs) in the TBX21 promoter, T-1993C and T-1514C, have been shown by statistic studies to associate with systemic lupus erythematosus...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-011-0597-6
更新日期:2012-05-01 00:00:00
abstract::Here we describe the Immunogenetic Management Software (IMS) system, a novel web-based application that permits multiplexed analysis of complex immunogenetic traits that are necessary for the accurate planning and execution of experiments involving large animal models, including nonhuman primates. IMS is capable of ho...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-011-0587-8
更新日期:2012-04-01 00:00:00
abstract::Immunoglobulin (IG) gene rearrangement and expression are central to disease resistance and health maintenance in animals. The IG kappa (IGK) locus in swine (Sus scrofa domestica) contributes to approximately half of all antibody molecules, in contrast to many other Cetartiodactyla, whose members provide the majority ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-011-0589-6
更新日期:2012-04-01 00:00:00
abstract::Position 45 represents a highly polymorphic residue within HLA class I alleles, which contacts the p2 position of bound peptides in 85% of the peptide-HLA structures analyzed, while the neighboring residues 41 and 46 are not involved in peptide binding. To investigate the influence of residue 45 at the functional leve...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-011-0583-z
更新日期:2012-03-01 00:00:00
abstract::Insect bite hypersensitivity (IBH) is a chronic allergic dermatitis common in horses. Affected horses mainly react against antigens present in the saliva from the biting midges, Culicoides ssp, and occasionally black flies, Simulium ssp. Because of this insect dependency, the disease is clearly seasonal and prevalence...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-011-0573-1
更新日期:2012-03-01 00:00:00
abstract::Drosophila larvae react against eggs from the endoparasitoid wasp Leptopilina boulardi by surrounding them in a multilayered cellular capsule. Once a wasp egg is recognized as foreign, circulating macrophage-like cells, known as plasmatocytes, adhere to the invader. After spreading around the wasp egg, plasmatocytes f...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-011-0571-3
更新日期:2012-02-01 00:00:00
abstract::Virus-specific CD8(+) T cells play an important role in controlling HIV/SIV replication. These T cells recognize intracellular pathogen-derived peptides displayed on the cell surface by individual MHC class I molecules. In the SIV-infected rhesus macaque model, five Mamu class I alleles have been thoroughly characteri...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-011-0541-9
更新日期:2011-12-01 00:00:00
abstract::The peptide repertoire presented on human leukocyte antigen (HLA) class I molecules is largely determined by the structure of the peptide binding groove. It is expected that the molecules having similar grooves (i.e., belonging to the same supertype) might present similar/overlapping peptides. However, the extent of p...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-011-0552-6
更新日期:2011-11-01 00:00:00
abstract::The presentation of identical peptides by different major histocompatibility complex class I (MHC-I) molecules, termed promiscuity, is a controversial feature of T cell-mediated immunity to pathogens. The astounding diversity of MHC-I molecules in human populations, presumably to enable binding of equally diverse pept...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-011-0538-4
更新日期:2011-09-01 00:00:00
abstract::Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting 0.5-1% of the population worldwide. The disease has a heterogeneous character, including clinical subsets of anti-citrullinated protein antibody (ACPA)-positive and APCA-negative disease. Although the pathogenesis of RA is poorly understood, progress ...
journal_title:Immunogenetics
pub_type: 杂志文章,评审
doi:10.1007/s00251-011-0528-6
更新日期:2011-08-01 00:00:00
abstract::Natural-killer group 2 member D (NKG2D) is an activating receptor that plays an important role in the immune response mediated by NK cells, γδ(+) T cells, and CD8(+) T cells. In humans, MHC class I chain-related genes and UL-16 binding protein (ULBP)/retinoic acid early transcript 1 (REAT1) gene family encode ligands ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-011-0531-y
更新日期:2011-08-01 00:00:00
abstract::Parasites exert a selection pressure on their hosts and are accountable for driving diversity within gene families and immune gene polymorphisms in a host population. The overwhelming response of regulatory T cells during infectious challenges directs the host immune system to lose the ability to mount parasite specif...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-011-0524-x
更新日期:2011-07-01 00:00:00
abstract::The rabbit has long been a model for studies of the immune system. Work using rabbits contributed both to the battle against infectious diseases such as rabies and syphilis, and to our knowledge, of antibodies' structure, function, and regulated expression. With the description of rabbit Ig allotypes, the discovery of...
journal_title:Immunogenetics
pub_type: 杂志文章,评审
doi:10.1007/s00251-011-0533-9
更新日期:2011-07-01 00:00:00
abstract::Macrophages (mϕ) from pre-diseased mice of the major murine inbred models of spontaneous autoimmunity (AI), including multiple lupus-prone strains and the type I diabetes-prone NOD (non-obese diabetic) strain, have identical apoptotic target-dependent abnormalities. This characteristic feature of mϕ from AI-prone mice...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-010-0507-3
更新日期:2011-05-01 00:00:00
abstract::Experimental infection of Mauritian cynomolgus macaques by simian immunodeficiency virus is a representative model of HIV infection, currently in favour for evaluating the efficacy of new preventive or curative treatments. Extensive studies of major histocompatibility complex (MHC) polymorphism by microsatellites reve...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-010-0504-6
更新日期:2011-05-01 00:00:00
abstract::Mammalian interleukin-4 (IL-4) and IL-13 are T helper type 2 (Th2) cytokines with pleiotropic functions in immunity. They signal through receptors containing IL-4Rα and IL-2Rγ or IL-13Rα1. In addition, a decoy receptor, IL-13Rα2, is known to exist and modulates the function of IL-13. The existence of fish orthologues ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-010-0508-2
更新日期:2011-04-01 00:00:00
abstract::Genetic variation in the major histocompatibility complex (MHC) is directly correlated to differences in disease resistance. Immunity is greatly dependent on highly polymorphic genes in the MHC, such as class I, class II, and class III complement genes. Preliminary studies of wild turkey populations show extreme polym...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-010-0501-9
更新日期:2011-04-01 00:00:00
abstract::The polymorphism of exon 2 of the DAB genes (major histocompatibility complex [MHC] class IIB) was investigated for the first time in the freshwater cyprinid fish species, Squalius cephalus, in the wide range of its distribution in Europe. We identified 111 different MHC class IIB variants in 15 chub populations distr...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-010-0495-3
更新日期:2011-03-01 00:00:00
abstract::Genes encoded by the major histocompatibility complex (MHC) play key roles in the vertebrate immune system. However, our understanding of the evolutionary processes and underlying genetic mechanisms shaping these genes is limited in many taxa, including amphibians, a group currently impacted by emerging infectious dis...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-010-0476-6
更新日期:2010-12-01 00:00:00
abstract::Zaïre ebolavirus (ZEBOV) infection rapidly outruns the host's immunity and leads to death within a week. Fatal cases have been associated with an aberrant innate, proinflammatory immune response followed by a suppressed adaptive response leading to the rapid depletion of peripheral NK cells and lymphocytes. A critical...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-010-0480-x
更新日期:2010-12-01 00:00:00
abstract::Nonaspanins constitute a family of proteins, also called TM9SF, characterized by a large non-cytoplasmic domain and nine putative transmembrane domains. This family is highly conserved through evolution and comprises three members in Saccharomyces cerevisiae, Dictyostelium discoideum, and Drosophila melanogaster, and ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-010-0472-x
更新日期:2010-10-01 00:00:00
abstract::We recently demonstrated that vaccinated rhesus macaques controlled viral replication of a heterologous SIV challenge. Here, we analyzed anamnestic SIV-specific CD4+ T-cell responses expanding immediately after challenge and show that successful vaccinees consistently targeted a short region of the Gag-p27 Capsid (ami...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-010-0473-9
更新日期:2010-10-01 00:00:00
abstract::Development of an accurate and efficient molecular-based equine MHC class I typing method would facilitate the study of T lymphocyte immune responses in horses. Here, a DNA microarray was designed to detect expressed classical MHC class I genes comprising serologically defined equine leukocyte antigen (ELA)-A haplotyp...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-010-0463-y
更新日期:2010-09-01 00:00:00
abstract::The genes of the major histocompatibility complex (MHC) are amongst the most variable in vertebrates and represent some of the best candidates to study processes of adaptive evolution. However, despite the number of studies available, most of the information on the structure and function of these genes come from studi...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-010-0456-x
更新日期:2010-08-01 00:00:00
abstract::As genetically engineered mutant mice deficient in single genes are usually generated on a C57BL/6 background, to study mast cell trafficking in mutant mice, we initially investigated whether mast cells accumulated in bronchi in C57BL/6 mice challenged with OVA allergen acutely or chronically for 1 to 3 months. The to...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-010-0452-1
更新日期:2010-08-01 00:00:00
abstract::KIR2DL5 alleles were physically linked to alleles at adjacent KIR loci to define this region of KIR haplotypes in 55 gene-positive random African Americans. The majority carried KIR2DL5B. Three KIR2DL5A and six KIR2DL5B alleles that have been previously described and 11 novel KIR2DL5 alleles were identified by DNA seq...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-010-0458-8
更新日期:2010-08-01 00:00:00
abstract::Genomic copy number variants (CNVs) are a common, heritable source of inter-individual differences in genomic sequence. Their influence on phenotypic variability and their involvement in the pathogenesis of several common diseases is well established and the object of many current studies. In the course of examining C...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-010-0459-7
更新日期:2010-08-01 00:00:00